"Burnout is caused by resentment" /April 30, 2013 by Jordan Isip Burnout is caused when you repeatedly make large amounts of sacrifice and or effort into high-risk problems that fail. It’s the result of a negative prediction error in the nucleus accumbens. You effectively condition your brain to associate work with failure. — Never head Burnout explained so well. From a comment on “Burnout is caused by Resentment”.